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1994-10-25
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Document 2401
DOCN M94A2401
TI Nutritional abnormalities in HIV-1 infected female drug users (IDUs).
DT 9412
AU Baum M; Carcamo C; Quesada J; Page BJ; Fletcher MA; Shor-Posner G;
Department of Epidemiology, University of Miami School of; Medicine, FL.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):312 (abstract no. PC0178). Unique
Identifier : AIDSLINE ICA10/94370174
AB OBJECTIVE: To characterize nutritional status, which may be an important
cofactor in determining the course of HIV-1 disease progression, in
HIV-1 seropositive and seronegative female IDUs. METHODS: Standard
methodology was used to determine plasma zinc, prealbumin and vitamins
A, E, B6 and B12 in 29 females. Ten were HIV-1+ with a mean CD4 cell
count of 390 +/- 190 cumm, and 19 were HIV-1 seronegative female control
IDUs (mean CD4 cell count of 1077 +/- 305 cumm). RESULTS: Eighty percent
of the HIV-1 infected females and 74% of the seronegative controls
exhibited at least one nutritional biochemical deficiency. Whereas
inadequate vitamin B12 status (< 240 pg/ml) was demonstrated in 40% of
the seropositive females, none of the seronegative women exhibited
inadequate vitamin B12 levels. In addition, a higher proportion (80%) of
low plasma zinc levels (< 0.85 mg/ml) was observed in the seropositive,
as compared to 47% of the seronegatives with marginal/deficient levels
of zinc. The mean values for prealbumin were similar and within the
normal range for the HIV-1 seropositive and seronegative females.
Biochemical deficiencies of vitamin A (< or = 0.3 mg/ml) and vitamin E
(< or = 5 mg/ml) were particularly widespread, occurring in 60% of the
seropositive and and 58% of the seronegative IDUs. DISCUSSION AND
CONCLUSIONS: Nutrient abnormalities, which are prevalent in seropositive
and seronegative female IDUs, may reflect poor dietary intake and be
related to drug-nutrient interactions. Low levels of vitamin B12 and
zinc appear to be affected by HIV-1 status, and may influence HIV-1
disease progression and HIV-1 viral activity.
DE Female Human HIV Infections/*COMPLICATIONS HIV Seropositivity *HIV-1
Nutrition Disorders/*COMPLICATIONS/DIAGNOSIS Prealbumin/ANALYSIS
Substance Abuse, Intravenous/*COMPLICATIONS Vitamins/BLOOD Zinc/BLOOD
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).